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About 10% of molecular oxygen undergoes ROS-yielding stepwise reduction during such physiological processes as mitochondrial respiration, CYP-mediated processing of endogenous lipophilic compounds, phagocytosis, and synthesis of disulphide (S-S) bonds from cysteine that are needed for proper protein folding in the endoplasmic reticulum (ER) (143)
O., Madureira, D., Rocha, L
R., Roberts, M
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This diversity leads to varying responses to treatment and refractory symptoms still occur in patients with severe disease [6]
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