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Research Applications of the AOD-9604 Peptide Adipocyte lipolysis assays in 3T3-L1 cells, primary human adipocytes, or rodent fat-cell preparations, measuring glycerol release and free fatty acid output as a functional readout of fragment activity

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Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)

Eflornithine, a medication developed for African trypanosomiasis, is also indicated to treat facial hirsutism

Nat Rev Mol Cell Biol 4(7):566577 van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JP (2012) Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy