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However, because they initially absorb through oral membranes, bypassing the stomach to go straight to the bloodstream, they shouldnt need as high of a dose.6 Research indicates a certain amount of difficulty absorbing peptides through regular digestion, so sublingual absorption could prove superior.7 The only problem is that sublingual delivery mechanisms for semaglutide haven't been tested to establish an effective dose outside of the compounding pharmacy industrys internal publications, which are more marketing materials than clinical research
For nausea, a relation with the inhibiting effects on gastric emptying seems plausible
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If you have kidney disease or take high doses of metformin, your doctor should monitor kidney function more closely when starting tirzepatide, since significant weight loss and improved glucose control can shift your renal metabolic load
