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A landmark randomized, cross-over clinical trial published in the International Journal of Clinical Nutrition & Dietetics by [Fanelli et al

NichollsSJBhattDLBuseJBPratoSDKahnSELincoffAMet alComparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics

doi: 10.1371/journal.pone.0105186

Endothelial migration and angiogenesis research forms a second major application area, with scratch-wound assays, capillary tube-formation assays, and other in vitro preparations characterising combination effects across multiple model systems

Interestingly, these events were shown to be independent of calpain activity, a calcium-dependent protease also implicated in cell death processes