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First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Smith et al., 2021)

Immunity (2010) 32:76677

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Fouillard L, Chapel A, Bories D, Bouchet S, Costa JM, Rouard H, et al

This is one reason why proper storage and shipping practices are important parts of quality control