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Under the stimulation of oxidative stress, keratinocytes are induced to produce CXC chemokine ligand (CXCL) 16, which further recruits CXCR6 + CD8 + T cells and the infiltration of such T cells in the skin is followed by the loss of melanocytes in vitiligo lesions (Li et al., 2017)

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At appropriate levels, it can protect the gut barrier and increases the production of the antioxidant glutathione, which improves cellular defense against oxidative stressso the odd smelly fart every now and then shouldnt be cause for concern

3 Cell (2017) in vivo resultsIn aged and progeroid mice, FOXO4-DRI reduced senescent-cell burden and restored fur density, renal function and fitness