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Additionally, geographic bias may limit generalizability: a potential geographic bias exists, as a substantial proportion of the included trials were conducted in North America and Europe, limiting generalizability to underrepresented populations in Asia, Africa, and South America

Since the glucose-lowering effects of GIP have been shown to be impaired in patients with T2D, interest has focused on developing antidiabetic therapies based upon the actions of GLP-1 and GIP, the response to which remains intact

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Bioavailability is lower with oral forms, potentially requiring higher milligram doses to achieve equivalent effects