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The first wave of disruption is caused by a sudden loss of blood flow to the brain which can quickly lead to metabolic disturbances, inflammation, oxidative stress, and neuronal death, while the second wave occurs at the reperfusion of oxygenated blood into the affected area, putting oxidative stress on the system

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The alterations in amino acids that confer the distinct brain-specific characteristics of the GLUD2-derived enzyme occurred when the size of the brains of ancestors of humans and great apes increased

Angiogenesis 15 , 543554 (2012)

A co-culture-based model of human bloodbrain barrier: application to active transport of indinavir and in vivo in vitro correlation