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Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

The interplay of glucagon-like peptide-1 receptor trafficking and signalling in pancreatic cells

Notably, semaglutide treatment led to a reduction in heart weight, left ventricular mass, and wall thickness, indicating a reduction in cardiac hypertrophy ( Figure 1C )

Private prescriptions are also available through registered healthcare providers following appropriate assessment

Unlike intramuscular delivery, theres essentially no risk of nerve injury