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Thats because utilization of vitamin B12 (especially from supplements) depends on levels of other metabolic cofactors and acids

You are a strict vegan or vegetarian and need to replenish depleted stores quickly

Boosts Energy Levels Vitamin B12 plays a key role in red blood cell formation and nervous system functionhelping combat fatigue, low mood, and brain fog

A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)

Conclusion: Is a B12 Injection Right for You