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It is important to contextualise this risk: obesity itself is an independent risk factor for pancreatitis, as are conditions commonly associated with excess weight such as gallstones, hypertriglyceridaemia, and type 2 diabetes

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Why This Matters Reduced GLP-1 activity may show up as: Increased hunger or cravings Difficulty losing weight Rising fasting glucose or A1c Feeling like metabolism is working against you This is one reason many people are now prescribed GLP-1 medications alongside statins they help replace a pathway that may be underperforming

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GLP-1 medications can make fasting days more manageable by reducing hunger and supporting blood sugar regulation