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The effects of ER once-weekly have been compared to exenatide twice-daily and overall ER was more effective at improving glycemic control and caused less gastrointestinal side-effects although both compounds caused a similar degree of weight loss (Drucker et al., The efficacy of once-weekly ER (2 mg) was compared to that of once-daily liraglutide (1.8 mg) in a 26-week trial in T2DM patients (Buse et al., DPP-4 inhibitors The DPP-4 inhibitors mediate their action by inhibiting the enzyme DPP-4, which prevents the breakdown of GLP-1 and thereby increases endogenous GLP-1 levels
Metabolism: Clinical and Experimental, 60 (6), 749-753
10.1016/j.tibtech.2015.03.004 29
Quick answer: when GLP 1 therapy is and is not the right tool GLP 1 therapy can be a strong option when menopause weight gain is tied to insulin resistance, appetite dysregulation, visceral fat gain, or repeated plateaus despite consistent habits
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