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In particular, a prominent regulatory role of protein persulfidation seems apparent, perhaps because sulfide produced by this pathway may react with oxidized thiol groups

The blood-brain barrier: structure, regulation, and drug delivery

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Indeed, when these receptors are activated by uncontrolled levels of Glu they may disrupt BBB integrity, altering the expression of efflux transporters or reducing the number of tight junctions within the ECs ( All in all, the organization of these transporters within the BBB maintains and strictly controls the AA concentrations in brain extracellular fluid

The isoform 1 protein is composed of 662 amino acids and the isoform 2 protein is composed of 629 amino acids