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Intracellular activation of nitrofurantoin yields a radical anion that subsequently initiates Nrf2-dependent induction of glutamate-cysteine ligase and consequently a rise in glutathione
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Regulation of sulphation and glutathion conjugation of acetaminophen in isolated rat hepatocytes
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These research outcomes further highlight the critical role of structural biology, specifically protein crystallography, in the discovery of drugs
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