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However, no published switching study in an obesity population has directly measured weight loss outcomes following a semaglutide-to-tirzepatide transition
T., Dowling, A
Key highlights Tirzepatide is FDA-approved for type 2 diabetes and weight loss
Clinical practice guidelines suggest several scenarios where dose modification may be appropriate: Persistent gastrointestinal symptoms lasting beyond the first week of a new dose level may warrant extending that dose phase by an additional 2-4 weeks before further escalation
These pathway-level markers do not predict response to any drug, but they add context no licensure check captures
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