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Cardiovascular Safety Studies With DPP-4 Inhibitors The Clinical Guidance for Pharmaceutical IndustryDiabetes MellitusEvaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes established by the FDA in 2008 as a consequence of adverse safety signals of rosiglitazone has set up the requirement for novel diabetes medications to prove cardiovascular safety of these substances in comparison to standard therapy under glycaemic equipoise

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This evidence gap represents both the compounds promise and its current limitations

Treatment of mitochondrial disorders