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Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

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If you take a sublingual troche containing 100 mcg, perhaps 5-20 mcg is absorbed

The non-hormonal mechanism makes them safe to use alongside hormone therapy if desired