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In AD, melatonin is hypothesized to preserve skin integrity and maintain a functional skin barrier through its antioxidant properties, which include reducing lipid peroxidation and exerting anti-apoptotic effects (103, 104)

Patients who pick 8 PM Thursdays and stick to it outperform those who chase 'optimal' timing by shifting between mornings, afternoons, and evenings based on daily convenience

With oral supplements, it can take weeks to notice an improvement