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We first observed, in a previously published bulk RNA-seq dataset of MEFs undergoing in vitro reprogramming 40 , that Mtr and Cd320 were upregulated soon after OSKM induction, remaining high during the early and middle phases of reprogramming, ultimately stabilizing to levels above those measured in MEFs (Extended Data Fig

This is especially important when comparing NNMT inhibitor research with peptide-centered metabolic research topics such as tirzepatide and semaglutide or AOD9604

Reproductive and developmental safety are not established

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