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2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events A 2024 Meta-analysis of 13 multiple cardiovascular outcome trials has documented that GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)

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Serious but rare side effects include pancreatitis, gallbladder disease, gastroparesis, and thyroid C-cell tumour risk, the last of which is reflected in the medications boxed warning based on findings in animal studies

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Increased GIP signaling induces adipose inflammation via a HIF-1-dependent pathway and impairs insulin sensitivity in mice