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The study design included two rounds of a three-day vehicle-treated baseline phase, a three-day treatment phase, and a two-to-three-day washout phase

According to previous studies, LD growth depends on lipid synthesis genes such as DGAT2 and GPAT4, and the key to the growth of LDs is the recruitment of DGAT2 and GPAT4 to the LD surface 18

By activating multiple melanocortin receptors, particularly MC1R, Melanotan II has become one of the most extensively studied peptides for investigating melanin synthesis, skin pigmentation, ultraviolet (UV) response, and melanocortin receptor biology

P = 0.051) (Table 3 and Fig