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This timing is deliberate: the combination amplifies the natural growth hormone pulse that occurs during slow-wave sleep, making evening dosing significantly more effective than morning dosing for body composition and recovery goals

By targeting specific cellular pathways, it may support fat reduction, improve energy balance, and promote overall metabolic health

Antioxidants, 11(7), p.1374

Fat metabolism: IGF-1 LR3 increases lipolysis and enhances glucose metabolism

The parent protein was first isolated in the 1990s by a Croatian research group led by Dionis Sikiric, who would go on to publish the majority of foundational BPC-157 studies