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If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency.[4][7][9][12] The replenishment with parenteral cyanocobalamin causes a rapid and complete improvement of megaloblastic anemia and gastrointestinal symptoms caused by vitamin B12 deficiency
In adults, these areas present the greatest activity, with the midbrain and hypothalamus being the second and third most affected areas, respectively
No human trial has established a best time, meal rule, or split schedule
Van Someren JW
Peng, X., Luo, Z., He, S., Zhang, L
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