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Longevity & healthspan
When the NNMT enzyme is overactive, its often associated with insulin resistance, a condition where your cells dont respond well to insulin and cant easily take up glucose from your blood
Azuma K, Furuzawa M, Fujiwara S, Yamada K, Kubo KY (2015) Effects of Active Mastication on Chronic Stress-Induced Bone Loss in Mice
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The differential effects of these molecules could be explained by differences in their affinity for the GLP-1 receptor, especially variations in their binding kinetics, e.g., on/off rates
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