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Injection Site Reactions In ZEPBOUND-treated patients in a pool of Study 1 and 2, injection site reactions were more frequent in those with anti-tirzepatide antibodies (11.3%) compared to those who did not develop anti-tirzepatide antibodies (1%) [see Clinical Pharmacology (12.6)]
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Tirzepatide after semaglutide failure has been shown to produce continued weight loss in patients who had stopped responding to semaglutide
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