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This reaction is catalysed by the enzyme folate conjugase on the brush border of enterocytes in the proximal small intestine 887,888

No changes in electrocardiogram or worsening of liver or kidney function have been reported

If you experience any of the following while taking the Wegovy pill, contact a healthcare provider: Develop a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath Have trouble passing gas or ongoing constipation Experience severe or persistent abdominal pain that sometimes radiates to your back Have signs or symptoms of an allergic reaction, such as trouble breathing, swelling of your face, lips, throat, or tongue, or hives Become pregnant Bottom line The FDA approved Wegovy in pill form in December 2025

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With elevated GH and consequently higher IGF-1 levels, the entire repair cascade operates more efficiently