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Other GLP-1 agonists for diabetes or weight management include semaglutide, liraglutide, exenatide, dulaglutide, and lixisenatide
Specifically, it includes 2-aminoisobutyric acid (Aib) at positions 2 and 20 to enhance resistance to enzymatic degradation, and -methyl-leucine (-Me-Leu) at position 13 to optimize receptor binding
They tell us what happens when the most potent molecule in the field meets the patients whose physiology fights back hardest and the answer is that it does very well, just not as well, and at a tolerability cost that goes up in exactly the population least able to absorb it
Assess the patients coping strategies and provide guidance on healthy coping mechanisms
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