how were glp 1 drugs discovered

how were glp 1 drugs discovered Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions GLP-1 medications didn't start as

Name: how were glp 1 drugs discovered Reflections on the discovery GLP-1 as a satiety hormone: Implications for obesity therapy and future directions GLP-1 medications didn't start as
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doi:10.1038/ejcn.2017.132 Uchida Y, Kaneda T, Ono M, Matsuoka M, Nakamura U, Ishida A, Yamasaki Y, Takeo H, Sakurai T

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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)