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This preclinical data provides an excellent base for human safety and efficacy trials [25]
Monitoring Protocol for Patients Using Both Agents If a patient and their prescriber decide to proceed with concurrent use after informed consent, the following monitoring protocol applies
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Importantly, the IL1RAPCD3null control retained IL1RAP binding but lacks CD3 engagement, and failed to reduce tumor burden or extend survival, supporting that CD3 engagement is required for therapeutic activity (Fig
High salt concentrations interfere with copper chelation and can destabilize the peptide complex
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