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125 TianY.JiangW.GaoN.ZhangJ.ChenW.FanD.et al (2010)
A Cochrane systematic review of NAC for COPD exacerbations (39 RCTs, n=7,436) found that NAC and other mucolytics significantly reduced the frequency of acute exacerbations (OR 0.75, 95% CI 0.62-0.92) (Poole et al., Cochrane Database Syst Rev, 2019) [43]
They operate in separate biological pathways: glutathione functions in cellular redox balance and Phase II detoxification, while tirzepatide modulates incretin signaling to reduce appetite and improve insulin sensitivity
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