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The compound activates HGF/c-Met signaling in hippocampal and cortical regions at picomolar to nanomolar concentrations, suggesting efficient distribution to the brain regions most relevant to learning and memory
It also improves cognitive function, promoting better concentration and memory
Foundational mouse study (Baar et al., 2017, Cell) Designed FOXO4-DRI and showed selective senescent-cell clearance, with restored fitness, fur density, and kidney function in aged and chemotherapy-treated mice
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