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Based on previous investigations, L-carnitine can decrease the cells apoptosis through inhibiting the activity of caspases, ameliorating oxidative stress, and enhancing the antioxidant defense systems in various tissues [23, 24]
These results concurred with a partial reduction of eWAT and iWAT depots and a lower effect of G49 in increasing in UCP1 protein levels in BAT (Fig
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The PI3K/Akt pathway activated by IGF1R is a major anti-apoptotic pathway in neurons, which drives interest in IGF1R agonism as a potential neuroprotective strategy in preclinical research
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