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Single-cell differential gene expression analysis between hepatocytes from semaglutide-versus vehicle-treated animals revealed a strong upregulation of genes involved in amino acid biosynthesis and metabolism, a trend shared across nearly all hepatic cell types ( Figure 6D-E )
It has not yet received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and therefore remains unavailable as a licensed treatment in the UK at this time
Cell Metab 15:675690
Yoshino J, Mills KF, Yoon MJ, Imai S-i
Pediatrics, 144 (5), Article e20183218
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