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"Decades of research have gradually revealed a much more complex picture of metformin's action, expanding the initial perspective of AMPK-dependent hepatic glycemic improvement to multiple modes of action across peripheral organs," Fukuda and his team explain in their paper

However, both medication classes can affect nausea, appetite, and gastrointestinal function

The brain receptors, though less numerous than GLP-1 receptors, might contribute to metabolic regulation through central mechanisms

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