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Most users find that injection site reactions during dose escalation follow the same diminishing pattern they experienced during initial treatment, peaking during the first 1 to 2 injections at the new dose and resolving by the third or fourth injection at that level

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Further, the GLP-1 receptor agonist wave has reduced the psychological block to self-injection

Avoid strenuous exercise, hot baths, saunas, and massage of the injection area during this period, as heat and activity increase blood flow to the site and worsen bruising

Many people achieve remission, especially with significant weight loss