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These results suggest that sublingual and oral B12 supplementation may serve as viable alternatives to IM injections, particularly in clinical settings where frequent intramuscular administration is impractical or resource intensive

Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

[5] In the same 28-day study, DIO mice showed reduced body weight and fat mass gains alongside improved glucose tolerance and attenuated hepatic steatosis

This mechanism enhances fat metabolism and supports body composition improvement without affecting blood glucose, insulin sensitivity, or IGF-1 levels like full-length growth hormone would