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3, transmural

In addition to these physiological regulators, other factors directly impact IGF-1 levels, such as chronological age, diseases altering IGF-binding protein (IGFBP) concentrations, and sampling variations in IGF-1 [Citation9]

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Glutathione levels naturally decline with age, but maintaining them can help slow the aging process by reducing cellular damage and supporting energy production

Older people are often detected to have a more potent vitamin B12 deficiency, even in cases where they do not suffer from pernicious anaemia