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Native amylin is notoriously difficult to work with because it aggregates to form amyloid fibrils (a property exploited by the pancreatic amyloid deposits seen in T2D progression)

Conversely, medications like metformin, H2 blockers, and proton pump inhibitors can reduce the absorption of Vitamin B12

Answer: The most common side effects of amylin analogs are gastrointestinal, including nausea, reduced appetite, and occasional vomiting or constipation, and they are usually mild, dose-related, and managed by slow titration

People who want once-weekly convenience Unlike older amylin medications that required three daily injections, cagrilintide's extended half-life of about a week means you only inject once weekly

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