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The production of testosterone is regulated by a complex interplay of hormones, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH) released by the pituitary gland
These are essential risk factors, but they do not tell the entire biological story
High levels of the transcription factor NRF2 can induce metabolic reprogramming in dormant tumor cells, re-establishing redox homeostasis and de novo synthesis of nucleotides, accelerating the activation of tumor cells and tumor recurrence
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