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Gastroenterology 133(2):659672
95 Furthermore, other literature suggests that JS-K inhibits angiogenesis, 96 induces cell apoptosis (a process related to PARP, caspase 8 and 9 cleavage, and cell differentiation), 95,97 destroys double-stranded DNA, 95,9799 and is also able to interfere with the cell cycle and its respective signaling pathways
8,9 Furthermore, smokers inhale 1 g of iron per 25 cigarettes and the smoke itself releases iron from ferritin, giving the lung surface fluid ample iron to generate the toxic hydroxyl radical through the Haber-Weiss and Fenton reactions
[7] Such large doses are administered under direct medical supervision and via IV drip to ensure safety
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