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According to the Semaglutide Treatment Effect in People with Obesity (STEP) program studies, people with overweight or obesity (without T2DM) who received semaglutide 2.4 mg and underwent lifestyle interventions experienced an average weight reduction of 14.7- 17.4% [116]
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Its role in several intracellular processes is well known
Moreover, because discontinuation of GLP-1RAs often leads to weight regain, these medications must be regarded as a chronic therapy to sustain weight loss and prevent associated negative health outcomes
