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Funding This work was supported by the 15th Batch of Emerging Frontier Project Topics of Shanghai Shenkang (to Changqian Wang, #SHDC12023123), the Clinical Research Program of Shanghai Ninth Peoples Hospital (to Jun Gu, #JYLJ202209), Shanghai Municipal Health Commission (to Jun Gu, #202240149), the National Natural Science Foundation of China (to LinGao,#82100462) and the Science and Technology Planning Project of Yunnan Province of China (to YangZhuo,#202402AA310073)

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Moreover, elevated systemic concentrations of TMAO enhanced thrombosis potential in vivo in animal models (4), and in recent clinical intervention studies, elevation in plasma TMAO induced with dietary choline supplementation altered platelet hyperresponsiveness in subjects (omnivores and vegans/vegetarians alike), as monitored by platelet aggregometry (17)

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