Various studies have attempted to quantify how much fat versus muscle mass is being lost when using GLP-1 agonists and the results vary anywhere from 20 to 50% of total weight loss as lean body mass (3) (muscle mass)
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These studies have provided important clues to understand the mechanism of action of carnitine in different pathological states and laid the foundation for the development of new therapeutic strategies
Deducing from these results, leukemic transformation as a result of iron overload is a valid hypothesis but data are still ambiguous and more prospective trials are required
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