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Zwitterionic polypeptides bearing carboxybetaine and sulfobetaine: synthesis, self-assembly, and their interactions with proteins

As different health care systems use different thresholds for clinically significant PCO, including whether patients experiencing severe cognitive decline or other major health issues are candidates for treatment, this can lead to differences in reported PCO rates among populations to arise solely from differences in clinical decision making (108, 109)

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ARA-290 (cibinetide) is the most advanced, with Phase 2 data on diabetic neuropathy (NERVARA trial)

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