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Kaklamanos et al., 2021

These clinical decisions correspond to exacerbation or attenuation of the TBI-induced reduction in GI microbiome diversity over time [109]

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In vitro studies demonstrate maximal NF-B inhibition at KPV concentrations between 110 micromolar (M), with diminishing returns above 50 M and paradoxical pro-inflammatory signaling observed at concentrations exceeding 100 M in some cell types

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