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[16] [18] Current clinical guidelines recommend caution and individualized decision-making, given the lack of robust safety data for high-dose injectable vitamin C in pregnancy and lactation

Direct stimulation of NADP(+) synthesis through Akt-mediated phosphorylation of NAD kinase

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injected, essentially all of it reaches circulation

They include: N-acetyl-cysteine (NAC) quickly metabolizes into intracellular glutathione