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This comparison focuses on four compounds that define the current state of the field: semaglutide (the established benchmark), tirzepatide (the dual-agonist leader), retatrutide (the triple-agonist frontier), and orforglipron (the oral non-peptide breakthrough)

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Understanding this potential complication is essential for healthcare professionals and patients to optimise safe, effective use of GLP-1 medications

The transition from 0.25mg to 0.50mg is the most common point for nausea to appear or worsen

For more detailed instructions, please consult your healthcare provider or pharmacist