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It is also posited to result in greater GH-synthesis response from the somatotroph cells

While in many mammalian species UA is further degraded to allantoin, in humans and certain other primates the uricase activity responsible for this metabolic removal has been lost

This susceptibility poses a serious threat to human health, contributing to approximately 2 million deaths annually, accounting for 4% of global mortality ( 4 )-induced acute liver injury model is widely used because it effectively mimics human liver conditions, such as acute liver injury, fibrosis, and oxidative stress ( Current treatments for liver diseases include antioxidants, hepatoprotective agents, anti-inflammatory drugs, and antivirals, all aimed at preventing or mitigating liver damage ( Glutathione, a key molecule involved in maintaining cellular redox homeostasis, has shown promise in protecting the liver from oxidative damage in various liver disorders

& Sunyaev, S