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Retatrutide and Tirzepatide | Side Effects and Safety Research into tirzepatide and retatrutide has yielded substantial insights into their potential side effects, with gastrointestinal issues being the most frequently reported across studies

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Kidney function appears in its clinical-factors table as one of five touchpoints a provider should address, and the narrative repeats that lupus often impairs renal clearance in ways that affect how the drug is handled

However, in comparison with placebo or basal insulin, tirzepatide increased odds of nausea, while the doses of 10 and 15 mg were also more likely to cause vomiting or diarrhoea