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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

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Personalized Weight Loss: How Genetic Testing Refines Your Treatment Choice Not every weight loss medication works equally well for every patient, and genetic variation accounts for a significant portion of individual response differences

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Training to prescribe both well The reason this comparison resists a tidy winner is the same reason weight-loss prescribing rewards real education: the field is broad, the tools are different, and the skill is in the matching